In a new study, scientists discovered a previously unknown process that led them to test the drug, which led to the treatment of a dangerous disease in rodents.
A research team from the University of Sao Paulo (USP) has made a major breakthrough in the treatment of heart failure, a disease that affects approximately 64 million people worldwide. New Atlas writes that during the research, a new pathological cellular mechanism that causes heart failure was discovered and a drug that could eliminate this failure was identified.
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A complex syndrome rather than a single disease, heart failure impairs the heart’s ability to pump adequate blood. Despite advances in treatment, it remains one of the leading causes of mortality and decreased quality of life.
The USP team found that heart failure is associated with the disruption of mitochondria, which are essential for cellular energy production. This can be likened to a car engine failing, resulting in reduced efficiency and increased toxic emissions. Specifically, they identified the harmful aldehyde 4-hydroxynonenal (4-HNE), which impairs the processing of microRNAs (miRNAs) as a byproduct of mitochondrial dysfunction. These small non-coding RNAs play a critical role in gene regulation, and their disruption is associated with various diseases.
Using mass spectrometry, the researchers found that 4-HNE binds to and inactivates Dicer, an enzyme important in miRNA production. This process was previously unknown and allows us to gain new insights into the mechanisms of heart failure.
The drug used in the study, AD-9308, restored Dicer activity and reversed the effects of heart failure by improving heart function in rodent models, the authors said. AD-9308 activates mitochondrial aldehyde dehydrogenase 2 (ALDH2), which detoxifies 4-HNE. As a result of treatment, the miRNA profile approaches that of a healthy heart.
This study provides new insights into the mechanisms of heart failure and offers a new potential therapeutic approach to improve patient outcomes.
Previously Focus He wrote that scientists were able to observe the first seconds of the heart starting in the embryo. Scientists who studied the first seconds of the heart’s life in a young embryo learned many interesting facts; for example, that the heart starts working before it is formed.
Moreover Focus The last of two men who survived a pig heart transplant had died, he wrote. The only survivor of two men who received a pig heart transplant died due to organ rejection despite positive signs of recovery. But the man contributed to science.
Important! This article is based on, and does not conflict with, the latest scientific and medical research. The text is for informational purposes only and does not contain medical advice. Be sure to consult a doctor to make a diagnosis.
Source: Focus
Ashley Fitzgerald is an accomplished journalist in the field of technology. She currently works as a writer at 24 news breaker. With a deep understanding of the latest technology developments, Ashley’s writing provides readers with insightful analysis and unique perspectives on the industry.