Researchers argue that the effect of the anti-aging drug depends on gender.
Technology Org, fruit fly research reveals how sex determines response to the anti-aging drug rapamycin.
The way a drug affects men and women can be drastically different. This has to do with rapamycin, the most promising anti-aging drug to date, according to researchers from the Max Planck Institute for the Biology of Aging and University College London in Cologne.
in 24News Breaker. Technology emerged telegraph channel. Subscribe so you don’t miss the latest and exciting news from the world of science!
They argue that the drug can only prolong the lifespan of female fertile flies, but not males. In addition, rapamycin only slowed the development of age-related pathological changes in the intestines of females. Therefore, the researchers concluded that biological sex is a determining factor in the effectiveness of anti-aging agents.
The life expectancy of women is significantly higher than that of men. However, they are more likely to suffer from age-related diseases and adverse drug reactions.
“Our long-term goal is to ensure that men live as long as women and women are as healthy as men in old age. But for that we need to understand where these differences come from,” explains one of the lead authors of the book. Examine Yu-Xuan Lu.
Researchers administered the anti-aging rapamycin to male and female fruit flies to study its effects on different sexes. Rapamycin is a cell growth inhibitor and immunomodulator widely used in cancer treatment and after organ transplantation. The scientists found that rapamycin extended lifespan in female flies and slowed the development of age-related intestinal pathologies, but not in males.
The scientists also noticed that rapamycin increased autophagy (the process of waste disposal by cells) in the intestinal cells of female flies. Male intestinal cells appear to have a high basal autophagy activity that rapamycin cannot further increase.
In addition to flies, this effect was replicated in mice. Female mice showed increased autophagy activity after treatment with rapamycin.
Yu-Xuan Lu said that female mice respond more to rapamycin than male mice to prolong lifespan, so this allows the fly to unravel the mechanism underlying these differences.
Linda Partridge, the study’s senior author, adds that gender may be a critical factor in the effectiveness of anti-aging drugs, and that understanding the processes that determine response to a therapeutic drug will improve the development of personalized therapies.
Previously Focus He wrote about a breakthrough in the treatment of autism. Scientists have managed to significantly improve social skills and brain function.
Source: Focus
Ashley Fitzgerald is an accomplished journalist in the field of technology. She currently works as a writer at 24 news breaker. With a deep understanding of the latest technology developments, Ashley’s writing provides readers with insightful analysis and unique perspectives on the industry.