The scientists’ innovative new development involves using previously unused methods to integrate immune cells, providing scientists with a new springboard in the fight against disease.
A team at the Medical University of South Carolina (MUSC) Hollings Cancer Center, in collaboration with Cincinnati Children’s Hospital Medical Center, has made significant progress in organoid research. They managed to create a three-dimensional miniature model of the colon, including immune cells. This success could pave the way for personalized approaches to treating colon diseases, including inflammatory bowel disease and cancer, writes New Atlas.
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What makes this development unique is the integration of immune cells into the organoid; this is often missing in similar models but is critical for studying organ behavior and disease states. These mini-organs, created using targeted human pluripotent stem cells, are similar to natural intestinal tissue in structure and function and contain many immune cells.
Lead author Jorge Munera emphasizes the value of this model by focusing on the role of the immune system in the development of gastrointestinal diseases. The immune cells of organoids, especially macrophages, proliferate the cells of the human body and have the ability to detect and destroy pathogenic bacteria. This similarity to human colon tissue increases its potential as a tool to study treatments for gastrointestinal diseases.
James Wells, one of the study’s authors, highlights the organoid’s potential for future medical research, noting that the composition of immune cells in it is almost identical to those in humans. This mini-colon not only mimics the lining of the human colon but also contains support and immune cells, creating a comprehensive system to study colon inflammation.
Researchers see this innovative organoid as a step towards personalized treatment. Using patient blood, especially in conditions such as early-stage inflammatory bowel disease, these organoids can be used to test the effectiveness of treatments before they are actually used, opening new opportunities for personalized medicine.
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Source: Focus
Ashley Fitzgerald is an accomplished journalist in the field of technology. She currently works as a writer at 24 news breaker. With a deep understanding of the latest technology developments, Ashley’s writing provides readers with insightful analysis and unique perspectives on the industry.