Thousands died and saved us: scientists have discovered a new stage of development of Alzheimer’s disease

Recently, scientists made an important discovery that sheds new light on Alzheimer’s disease and its mysterious development. They found that the unusual cell death associated with excess iron accelerated cognitive loss. New Atlas writes that this means we may be on the verge of a potentially new approach to solving the problem of disease.

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Researchers at Oregon Health and Science University (OHS) have identified for the first time the role of a special type of cell death called ferroptosis in the progression of Alzheimer’s disease. In simplest terms, ferroptosis is the death of cells due to excess iron. This process appears to destroy certain immune cells in the brain, particularly in Alzheimer’s disease and another type of cognitive decline called vascular dementia.

A group of researchers made a surprising observation while examining the brain tissue of people with dementia. They noticed that some of the brain’s immune cells, called microglia, were dying. Microglia are like the servants of the brain, they clean the waste. Unfortunately, during the cleansing process, they sometimes interact with the iron-rich substances that surround our nerves. When these materials are damaged, they release iron, which leads to ferroptosis and eventually causes our helpful workers, microglia, to die.

Neuroscientist at the NIH and senior author of the study, Dr. Steven Beck said he was surprised by the results: “Everyone knows that microglia help reduce inflammation in the brain. But it’s surprising to realize that such a significant number of people are dying. And we hadn’t noticed it before.”

While the idea of ​​targeting ferroptosis in Alzheimer’s is not new, this particular discovery offers a new way of looking at ways to combat the disease. Understanding that these microglial cells are at risk and the role of iron in this process allows the development of treatments that slow the development of neurodegenerative diseases.

Also, Dr. Beck stresses the importance of shifting our focus to the damage to the white matter of the brain and the fragility of these microglial cells, and says these aspects have not been the focus of attention before.

The expert group is optimistic. The results could help pharmaceutical companies develop drugs that protect these microglial cells. Dr. Back shared his thoughts on the matter: “A discovery like ours could generate significant interest in compounds with therapeutic value in the pharmaceutical industry.”

But early intervention is still critical. Cognitive decline is a gradual process that usually begins after events such as stroke or chronic diseases such as high blood pressure and diabetes. To really change the situation, it is necessary to deal with it at the earliest stages. This discovery thus paves the way for understanding and possible treatment for Alzheimer’s disease, which has the potential to change countless lives in the future.

Previously Focus He wrote that scientists have recently seen microglia as a new culprit in the development of Alzheimer’s disease. Deep in our brains are cells designed to protect it, but they apparently lead a double life and can cause disease.

Moreover Focus He wrote that scientists say you can fight Alzheimer’s disease with the help of food. As research shows, it is possible to significantly improve the condition of a person with Alzheimer’s disease if you take long breaks from eating.

This material is for informational purposes only and does not contain advice that may affect your health. If you have problems, consult a professional.