Scientists have identified unusual and beneficial properties in an existing drug for a deadly disease and aimed to use it to combat other common and dangerous diseases.
Scientists at the University of Cambridge have discovered a new potential use for polo-like kinase 1 (PLK1) inhibitors, drugs primarily being investigated for cancer treatment. The focus of their research is on a molecule called NLRP3, which triggers inflammation in the presence of a perceived threat. New Atlas writes that this inflammatory substance can sometimes become overactive, contributing to the development of serious inflammatory diseases such as gout and heart failure.
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In gout, inflammation occurs due to excess urate crystals in the joints, and in heart attacks, the immune system reacts aggressively to dead cells in the heart muscle, worsening the damage. PLK1, a molecule known for its role in regulating cell division, also affects the NLRP3 inflammasome. It especially plays a role in the organization of microtubule cytoskeletons (channels that provide internal transport of matter) in cells.
In experiments in mice, the Cambridge team found that a PLK1 inhibitor could create a barrier to these cellular channels and attenuate the inflammatory response by controlling NLRP3 activity in non-dividing cells. The lead author of the study, Dr. Xuan Li explained that by disrupting microtubules, they can reduce the inflammatory response, potentially preventing conditions that cause pain, disability, and even life-threatening complications.
The team is now continuing to test the PLK1 inhibitor in inflammatory diseases in human clinical trials. Considering that these drugs have been tested for safety in treating cancer, Dr. Lee hopes to see rapid progress in clinical and regulatory processes; This could lead to new treatments for a variety of inflammatory diseases that are available to everyone.
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Important! This article is based on, and does not conflict with, the latest scientific and medical research. The text is for informational purposes only and does not contain medical advice. Be sure to consult a doctor to make a diagnosis
Source: Focus
Ashley Fitzgerald is an accomplished journalist in the field of technology. She currently works as a writer at 24 news breaker. With a deep understanding of the latest technology developments, Ashley’s writing provides readers with insightful analysis and unique perspectives on the industry.