Turned off internal sensor: Scientists eliminate cold response in mice

A new study by scientists identified a specific protein that eliminates any reaction to cold in mice. This discovery could provide the basis for the development of many treatments for complex diseases and conditions.

Researchers at the University of Michigan have made a groundbreaking discovery in understanding how mammals, including humans, perceive cold. They discovered a protein called GluK2 that acts as an unusual temperature sensor. This discovery closes a long-standing gap in the biology of sensory organs that scientists have been trying to fill. ScienceDaily writes that proteins responsible for the perception of different temperature conditions such as heat, hot and coldness have previously been identified, but the mechanism for detecting cold at temperatures below 15.5 degrees has not been identified.

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The discovery was based on previous work in the tiny worm Caenorhabditis elegans, where a cold-sensitive receptor was identified for the first time. The fact that the gene responsible for this protein in worms is common to many species suggests that the same or similar protein may play a role in the cold response in mammals. By examining mice lacking the GluK2 gene, the researchers observed that these mice responded normally to other temperatures but not to cold; This suggests that GluK2 plays a strong role in cold sensation.

The importance of discovering the role of GluK2 extends beyond basic science; It has practical importance for human health. Understanding how this protein mediates the sensation of cold could lead to new treatments for diseases in which cold sensitivity is altered; for example, in chemotherapy patients who often experience a painful reaction to cold. This research advances our fundamental understanding of the biology of sensory organs and holds promise for improving the quality of life of many people with altered temperature sensitivity.

Previously Focus He wrote about the benefits of cold in extending life. Low temperatures could be key to discovering new treatments for neurodegenerative diseases.

Moreover Focus He wrote about the health dangers of freezing winter weather. Researchers listed risks ranging from effects on the immune system to heart attack, anxiety and depression.

Source: Focus

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