edit Human DNA has been the target of many scientists, and a recent study shows that they have been discovered safe places to introduce genes into human DNAwith which, according to scientists, “Google Maps” of genome editing were created.
scientists from Saint Jude Children’s Research Hospital developed a tool able to find safe places to introduce genes into human DNA.
Research published in the journal Genomic biology emphasizes that this tool is considered first step in the improvement process safety and efficacy of gene and cell therapy.
“We created Google Maps for genome editing”says study co-author Yong Cheng, a physician in the hematology department at St.
The specialist notes that with this tool they provide a new approach to identifying places where safely integrate the gene cassette.
“We have created step by step instructionsso you can follow instructions and easily find safe spots in certain tissues,” he adds.
Currently gene therapy has proven to be effective in the treatment of certain genetic diseases. However, there have been safety concerns, such as inadvertent activation of an oncogene that caused cancer in some patients.
Faced with this problem, Scientists search for “safe places” in the genomea, into which a gene can be introduced without causing cancer or other problems.
Scientists at St. Jude Children’s Research Hospital have developed a system to find safe places from genomic and epigenetic information certain tissues, such as blood cells.
A new way to find safe places
Tool created compare DNA sequences more variables among healthy people using data from the 1000 Genomes Project.
The researchers concluded that if a piece of DNA is frequently removed or inserted in healthy people, then it probably is. can be safely modified with the help of gene therapy.
“Our method is new way to identify safe genomic sites specifically for each fabric,” says Cheng.
After several tests, scientists confirmed that genes placed in safe places defined by your tool they kept their expression with time.
Finally, the researchers also showed that if they put the gene in one of the safe places determined by their instrument, nearby genes are less affected than a classic safe place.
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Source: La Opinion
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