Researchers hope that by 2030 the drug will be available to humans and dentists will be able to replace lost teeth with new teeth.
Everyone knows that teeth don’t regrow when we’re adults – in fact, any wear and tear is irreversible. Still, scientists have been working to change this for decades, and they seem to be as close as they can get to solving the problem today, writes Science Alert.
Previously, Japanese scientists have already conducted successful animal studies and are now preparing to begin clinical trials in humans. According to a team from the Kitano Hospital Medical Research Institute in Japan, the drug was initially aimed at patients with anodontia, a rare genetic disease that inhibits the normal growth of deciduous and adult teeth.
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Initially, treatment is expected to focus on young children with this disease, but it is thought that the drug could be used in the future for patients with other diseases, such as gum disease.
Katsu Takahashi, head of the Department of Dentistry and Oral and Maxillofacial Surgery at Kitano Hospital, said the team plans to begin clinical trials of a potential dentifrice agent as early as July 2024. If successful, the researchers expect therapeutic drugs to be available to patients as early as 2030.
In an animal study, scientists found a link between a particular USAG-1 gene and tooth growth restriction in mice. The researchers then moved on to tests that tried to block expression of this gene. As a result, they were able to find an antibody that could safely block some of the gene’s activity in mice and ferrets. At the same time, scientists did not find any side effects.
The researchers say the next step is to see if the same chemical reactions can be controlled in humans. At the same time, scientists note that at the moment we are talking about potential, but not reality. But scientists hope the tests will be successful.
Previously Focus He wrote that scientists have learned to regrow healthy teeth.
Source: Focus
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